Exemestane 12.5mg (750mg)

How Exemestane works Exemestane acts as a false substrate for the aromatase enzyme. Aromatase inhibitors (AI) have been used in males in idiopathic short stature, constitutional delay of puberty, precocious puberty, gynecomastia, oligospermia, hypogonadism related to obesity and ageing. Exemestane results in men Both dosages were comparable in suppressing all circulating estrogens and had a similar impact of increasing serum androstenedione and testosterone concentrations. Results showed that a 38%, 71%, and 45% decrease in estradiol, estrone, and estrone sulphate concentrations. Respectively, after ten days of administration of the last dose, a 60% and 32% increase of testosterone and androstenedione were measured. The rise in the aromatase substrates, testosterone, and androstenedione, is probably secondary to the feedback increase in gonadotropins. The 21% decrease in SHBG concentrations was also expected. There are effects of aromatase inhibition on the release of the follicle-stimulating hormone. Although FSH release is primarily under the control of inhibin, circulating estradiol has an impact on men. The use of an AI results in a three-fold increase in levels of FSH in eugonadal men and may potentially stimulate sperm production. Aromataze Inhibitors in Men The third-generation aromatase inhibitors (AIs: anastrozole, letrozole, and exemestane) have now become standard. AIs block estradiol biosynthesis from androgens by inhibiting aromatase. Exemestane for sale Information provided here for educational use only.