Orlistat works by inhibiting fat absorption in the intestines, blocking about 30% of dietary fat from being absorbed. Orlistat is typically used in conjunction with a reduced-calorie diet and exercise program, similar to other weight loss products. However, its unique mechanism of action means it's particularly effective when combined with a low-fat diet. Orlistat can be used for extended periods as long as it continues to be effective. There's no restriction on duration if it has helped reduce weight by 5% or more after three months