GHRP-6 Growth Hormone Releasing Peptide-6

GHRP-6 has the amino acid sequence His-D-Trp-Ala-Trp-D-Phe-Lys-NH23. It is a stable compound that can be administered orally, although its bioavailability through this route is less than 1%. GHRP-6 acts as an agonist of the growth hormone secretagogue receptor (GHSR), also known as the ghrelin receptor. It stimulates GH release by activating pituitary somatotrophs directly, increasing membrane phosphatidylinositol turnover, activating protein kinase C (PKC), mobilizing intracellular calcium reserves. notably, GHRP-6's mechanism is cAMP-independent, distinguishing it from other GH stimulators. Beyond its primary role in stimulating GH release, GHRP-6 has demonstrated several other physiological effects: Cardioprotection: It has shown promise in preventing and attenuating cardiac cell death and left ventricular failure. Anti-fibrotic properties: GHRP-6 may help mitigate systemic complications in various experimental scenarios. Systemic cytoprotection: It has demonstrated protective effects on multiple organs, including the liver, lungs, kidneys, and small intestine, particularly in ischemia/reperfusion scenarios. Antioxidant effects: GHRP-6 has been associated with a reduction in reactive oxygen species generation and preservation of antioxidant defenses